A new paradigm for Cryo-EM

The world’s first event-based camera for high-throughput cryo-EM with no compromise in the QE and speed

  • Apollo - direct detection TEM camera for Cryo-EM

    Key Features

    • Highest throughput direct detector for cryo-EM; next generation sensor and camera architecture that performs electron counting in hardware in real time
    • Generating super-resolution (67 megapixel) dose fractionated frames at 60 frames per second (fps) thanks to completely New Approach to Electron Counting
    • Ultra-fast on-chip electron counting delivers a dramatic improvement in quality and speed, counting with up to 10x higher beam brightness, and a 10x shorter exposure time than other direct detectors
    • No more specific electrons/pixel/frame value dictated by the camera: TEM column, specimen, or methodology are now deciding for the values
    • 4k × 4k pixels with larger 8 μm pixel size to maximise resolution (MTF)
    • Making impossible possible: All This at Lower Cost

Apollo is the world’s first event-based direct detector and represents a paradigm shift for cryo-EM. As the next generation of electron counting TEM cameras, it acquires high SNR electron counting images almost 10x brighter than the previous brute-force software-based counting detectors.

With an all-new, purpose-designed event-based direct detection sensor with completely digital readout, noise is reduced and bottlenecks due to detector speed are eliminated.

On Chip CDS

Apollo uniquely feature on-chip CDS or correlated double sampling. In conjunction with on-chip thresholding and on-chip event detection, Apollo generated images with unrivalled quality.


The first beta testing of the Apollo with FPGA (Field Programmable Gate Array) architecture was carried out by Dr. Stephen Lutke and Dr. Zhao Wang at Baylor College of Medicine in Houston, Texas. The found that the Apollo maintains exceptional performance up to levels of about 60 electrons per pixel per second.

Dynamic Studies

The high-speed detection made possible with Apollo will enable researchers to produce electron counting movies with a high exposure rate. This will facilitate new dynamic techniques such as high-throughput continuous rotation tomography, in situ structural biology and studies of radiation damage.

  • All
  • Biological Microscopy
  • CL
  • CLEM
  • Diffraction Imaging
  • EBSD
  • EDS
  • Electron Beam Lithography (EBL)
  • Electron Microscopy
  • Fabrication
  • FIB
  • Hyperspectral
  • In situ
  • Laser spectroscopy
  • Micro XRD
  • Micro XRF
  • Microscopy
  • Protein
  • Protein Crystallography
  • Raman
  • SEM
  • Spectroscopy
  • TEM
  • Thermal Probe Lithography
  • WDS