Fluicell BioPen Systems

Microfluidics-based compound delivery

Precise control of the cellular micro environment via microfluidics

Key Features
- Target single cells Target just one or a small number of adherent cells to particular compounds
- Rapid delivery Deliver four different compounds to just a single cell or part of a cell with sub-second exchange time.
- Low compound consumption The four integrated wells containing less than 35 μl, overcome typical dead volume problem of external tubing, reducing significantly the use of expensive reagents.
- Combination with other probing devices The pipette tip has been optimized to fit into practically any micromanipulation environment allowing combination with other probes such as patch-clamp pipettes, optical fibers or electrodes.
- No glass or tip breakage The pipette tips are made from a flexible biocompatible material so that unlike glass pipettes they won’t break upon contact with the hard surface.
- No contamination The pipette tip has been developed from an hydrodynamically confined flow principle, enabling contamination-free confinement of one miscible liquid inside another.

Control the microenvironment of your cells by targeting one cell at the time.

The ability to target one or a small number of cells requires precision control over the environment immediately surrounding a cell.

BioPen PRIME and BioPen FLEX systems are easy-to-use microfluidic devices for maintaining a local delivery of molecules to single-cells, enabling control of the chemical environment around single intact cells in tissue or cell cultures.

Applications

Interaction between cells and nanoparticles play an important role in multiple biological and pharmacological processes, including:

Viral infection
Nanoparticle drug delivery
Exosome biology
Endocytosis

The BioPen system lets you study these process directly on a single-cell level using very small amounts of expensive or scarce sample solutions.

The Fluicell BioPen in Action

Collect unprecedented data quality at high resolution by controlling how much, when and where your compounds meet your cells.