The only cell-derived matrix that mimics the native niche in vitro. Get better results with CELLvo™.
Naturally derived 3D matrix for healthy, robust more physiological relevant cell culture studies. The next evolution in stem cell research.
CELLvo™ Matrix overcomes key obstacles to isolating and expanding clinically useful stem cell for research, diagnostic and therapeutic applications
This cell-free culture substrate provides a native three-dimensional microenvironment which can be used for isolation and rapid expansion of various cell types.
The only commercially available substrate that aims to recapitulate biochemical as well as structural and mechanical cues of the native niche by leaving the extracellular matrix intact.
The best cell culture environment for growing primary cells Healthier and robust cell growth. Cells adhere and grow naturally which means that they retain their phenotype.
Optically clear substrate Unobstructed investigation by optical microscopy
Is an extracellular matrix (ECM) of proteins synthesized and constructed by bone marrow stromal cells. This product is composed of more than 150 proteins that were secreted and assembled by bone marrow cells during the production of the CELLvo™ Matrix. The final product is cell-free with only the ECM attached to the surface of the culture vessel. This cell culture substrate provides a native three-dimensional microenvironment which can be used for isolation and rapid expansion of various cell types. For further information about the cells types, please visit CELLvo™Cells page on our AXT website.
CELLvo™ Matrix is the only commercially available substrate that aims to recapitulate biochemical as well as structural and mechanical cues of the native niche by leaving the extracellular matrix intact. Cell-derived matrices create a biologically-relevant culture environment for a variety of cell types by providing all the cues cells expect to receive in vivo in our culture dishes. This means that instead of responding to foreign culture conditions, cells respond to the customers’ experimental variables.
Cells used to produce CELLvo™Matrix are purchased from Lonza. The starting material, human bone marrow mononuclear cells, are procured from young, healthy individuals. The donors are screened for HIV and HepB.
Now in addition to CELLvo™Matrix you can also find CELLvo™Xeno-free Matrix.
CELLvo™Xeno Free Matrix has been shown to be similar in structure and composition to CELLvo™Matrix. In-house experiments have proven both to be effective in a solution or suspension format. This may be desirable for many applications including direct therapeutic use and bioreactor expansion of cells.
CELLvo™ Matrix has been used to:
Expand various types of MSCs (bone marrow, adipose, umbilical cord blood, umbilical cord tissue, amniotic fluid)
Support maintenance of human Islet cells
Evaluate effects on various types of cancer cells
Support germ cells (oocytes) in culture
To stimulate bone healing
In general, we recommend the research product for use with any hard to grow cell
Learn about the production and use of the CELLvo Matrix
The CELLvo Matrix is an Extracellular Matrix of proteins synthesized in vitro by bone marrow stromal cells. The product is composed of more than 150 proteins that were secreted and assembled by bone marrow cells during the production of CELLvo Matrix. The following animation describes this process in greater detail. The final product is cell-free with only the ECM attached to the surface of the dish. This cell culture substrate provides a native three -dimensional microenvironment, which can be used for rapid expansion of high quality mesenchymal stem cells.
Schematic of the production method for CELLvo™ Matrices.
Heat map of gene expression of cells after seeding onto TCP vs. CELLvo™ Matrix.
ENABLES XENO-FREE ISOLATION: ______________________________
With CELLvo™ XF Matrix, cells naturally home and adhere to their new niche. With a variety of cell types, we routinely see more rapid attachment and proliferation of primary cells.
(BM-MSC isolation from primary bone marrow mononuclear cells (100x) at day 14)