Scientists can use optical tweezers to trap beads and catch a filament with motor proteins bound to it in-between. This filament can then be manipulated by moving the beads, while the force and extension are measured. Combining optical tweezers with simultaneous fluorescence measurements allows visualizing the binding location of fluorescently-tagged motors along the filaments.

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Scientists can use optical tweezers to trap beads, as depicted at the right, and catch a filament in between. This filament can then be manipulated by moving the beads, while the force and extension are measured. Combining optical tweezers with simultaneous fluorescence measurements allows correlating the mechanical properties of the microtubule with local information.

For detailed application notes click here