Magnetic Particle Imaging – Momentum High Resolution Molecular Imaging System
Magnetic Particle Imaging (MPI) is a new ultrasensitive high resolution molecular imaging technique suited to researchers working in the field of preclinical imaging. It is able to unambiguously detect iron oxide tracer at nanomolar concentrations anywhere in the body and the workflow is no more difficult to use than optical imaging.
According to the International Workshop on Magnetic Particle Imaging:
“MPI is the most promising emerging imaging technology in the last 20 years and is expected to change the landscape of modern medical imaging and in vivo translational research.”
MPI is the perfect complement to other imaging modalities such as PET, optical and MRI. Furthermore, it holds fantastic potential for high resolution, sensitive quantitative imaging.
How Does MPI Work?
A “sensitive point” is generated using powerful magnets. This point is scanned across an animal subject. The iron oxide tracer agent nanoparticles that pass through the point generate a signal. This shows how the tissue functions.
MPI has the added advantage that is able to produce clear images with excellent contrast regardless of signal depth. This means that it can be used to investigate any part of the body, on subjects of any size.
MPI SPIO Tracers
MPI uses custom tracers such as single core SPIO (super-paramagnetic iron oxide) nanoparticles that are within the range 20-25nm. The sensitivity is such that MPI can detect less than 100 tagged SPIO cells and these can be tracked anywhere in the body of the subject.
MPI complements other imaging modalities and enables:
- Longer term monitoring of functional events thanks to long terms monitoring
- Quantitation without any tissue attenuation
- Potential clinical translation
MPI can be used for:
- Longitudinal cell tracking
- Blood Pool Imaging
- Cancer and tumour imaging – oncology
- Vascular function
- Stem cell, immune cell and cell tracking
- Multi-colour MPI
- Theranostic imaging
- Functional nanoparticles
- Image guided heating
How Does Magnetic Particle Imaging Work
MPI is a new imaging technique suited to preclinical imaging. It can directly detect iron oxide nanoparticle tracers using time varying magnetic fields. These tracers are introduced into the body and a positive signal from the particles has the same resolution and sensitivity regardless of depth. As a result, MPI images provide excellent contract and sensitivity giving you an unprecedented view of what is happening, or how your therapy is affecting the host.
Magnetic Nanoparticles Align with an Applied Magnetic Field
Under ambient conditions, the iron oxide nanoparticles will be randomly oriented and their magnetisation said to be unsaturated. When a magnetic field is applied, the nanoparticles align and their magnetisation becomes saturated and reaches a maximum.
Producing a Field Free Point (FFP) with a Strong Magnetic Field Gradient
By opposing two strong magnets a strong magnetic field gradient is induced a special magnetic field where the nanoparticles will become unsaturated as they pass through this position; the Field Free Point or FFP. Only nanoparticles passing through this point will produce a signal.
Producing a Signal by Rapidly Moving the FFP
By rapidly moving the FFP through the body , the SPIO nanoparticles passing through the FFP flip from an unsaturated negative value to a saturated positive value. This change in magnetic state induces a signal in a receive coil. By controlling the position of the FFP, the signal at this specific point can be assigned and hence an MPI image produced.
Advantages of MPI over Other Imaging Modalities
|Deep tissue imaging||Yes||Yes||Yes||Yes|
|<100 cell sensitivity at any depth, key for cell tracking||Yes||Yes|
|Vascular, functional and cell based technologies||Yes||Yes|
|Translatable to the clinic||Yes||Yes||Yes||Yes|
|Exquisite resolution ( <=1mm )||Yes||Yes||Yes|
|Long term tracer stability||Yes||Yes||Yes|
|Sensitivity||10ng Fe in <5min|
|FOV mouse||40 x 120mm|
Other key features include:
- Self-shielded architecture for flexible siting
- Imaging bore
• >=40 mm (Mouse)
• >=60 mm (Rat)- Optional & upgradable when available
- Gas anesthesia port
- High performance control computer
- 24-inch, high-resolution flat screen monitor
- 8” panel touch screen display for animal handling
- Acquisition software with intuitive subject set-up, acquisition, data viewing and DICOM export