Galileo Tissue Microarrayers (TMA) from ISENET

Integrated Systems Engineering srl (ISENET) is a leading manufacturer and supplier of Tissue Microarray systems (TMA). Tissue microarrayers enable the generation of hundreds of representative tissue samples that can then be simultaneously analysed using a variety of automated analytical techniques such as molecular biology or slide scanning technology.

With tissue microarrays, large numbers of samples are processed, enabling the rapid translation of results from research into clinical practice using large research studies from stored pathology samples.

TMA’s from ISENET range are semi-automatic computer-controlled systems. These systems offer the perfect blend of sample processing throughput, reliability and accuracy to ensure you produce the best possible samples for analysis from your valuable tissue samples. Furthermore, the semi-automatic nature of ISENET’s TMAs provides users the ability to validate the coring/depositing process ensuring no missed samples.  This approach ensures that accurate tissue microarrays are produced the first time and every time. This family of TMA systems has been designed to meet a range of capabilities and budgets.

Patented Technology

The system is protected by US Patent 6,669,710 and European Patent 1,068,528, all titled “Tumor Tissue Microarrays for Rapid Molecular Profiling”.

Applications

Tissue Microarray applications include:

  • Biomarker validation
  • Clinical biopsies
  • Cancer and tumour sampling
  • Oncology
  • Drug discovery
  • Immunohistochemistry
  • Fluorescent in situ hybridisation

Cell Array (CLA) applications include:

  • HTS of Stem Cell Lines and IPS

Galileo CK4500 Computer Driven Tissue Microarrayers

This highly advanced tissue microarrayer is able to work with different size tissue blocks thanks to its open architecture design. This enables you to create your own integrated tissue microarray pathology platform.

Key Features

  • Suited to standard, macro and custom tissue block cassettes up to 80x120mm
  • High resolution optics
  • Automated and computer-guided needle positioning helps avoid errors, improves accuracy and increases efficiency
  • High speed stage
  • Open architecture enables working with various size paraffin blocks
  • Cores can be dispensed into 96 well plates, strips or microfuge vials
  • Can be used with 1xmacro and 3xstandard tissue cassettes (Advanced version)
  • 1D and 3D barcode for total traceability
  • High speed automated tray with modular tissue block holder
  • High resolution digital camera
  • LED back lighting and reflected light illumination
  • Standard needles 0.6, 1.0, 1.5 and 2.0mm (max. sample depth 10mm), Custom needles 3.0 and 5.0mm (max. sample depth 10mm), Macro needles 1.0, 1.5 and 2.0mm (max. sample depth 15mm)

Video Demonstration

Click here for Video Demonstration.

Galileo CK3500 Computer Driven Tissue Microarrayers – Basic and Advanced

The CK3500 tissue microarrayer comes in two variants depending on what size tissue blocks you will be working with:

  1. Galileo TMA CK3500 Advanced – Suits both standard and macro tissue blocks
  2. Galileo TMA CK3500 Basic – for standard tissue blocks only

Key Features

  • High resolution optics
  • View images on your computer monitor with excellent resolution and 20x magnification
  • Save digital images for virtual superimposition and insertion into reports
  • High speed stage
  • Automatic changing and computer guided positioning of needles, increases control, reduces errors resulting in improved efficiency
  • 6 block automated tray precisely positions paraffin blocks
  • Simultaneously mount 1xmacro and 3xstandard cassettes (Advanced system)
  • Open architecture enables working with various size paraffin blocks
  • Cores can be dispensed into 96 well plates, strips or microfuge vials
  • 1D and 3D barcode for total traceability
  • High speed automated tray with modular tissue block holder
  • High resolution digital camera
  • LED backlighting and reflected light illumination
  • Standard needles 0.6, 1.0, 1.5 and 2.0mm (max. sample depth 10mm), Custom needles 3.0 and 5.0mm (max. sample depth 10mm), Macro needles 1.0, 1.5 and 2.0mm (max. sample depth 15mm)
  • CK3500 system are upgradable to CK4500 spec

Video Demonstration

Click here for Video Demonstration.

Galileo CK2500 Semi Automatic Tissue Microarrayer

The CK2500 is a semi automatic tissue microarray system that features a small footprint and in-built touchscreen user interface.

The system is protected by US Patent 6,669,710 and European Patent 1,068,528, all titled “Tumor Tissue Microarrays for Rapid Molecular Profiling”.

Key Features

  • Customisable arrays allows the user to configure: paraffin size, needle diameter, number of spots and spacing/pitch between spots
  • Automated stage – computer assisted operation facilitates fast and precision positioning of paraffin blocks
  • Stage has 6 tissue standard cassette holder
  • Automated and computer guided needle positioning including automated regulation of core insertion depth
  • Easy needle mounting
  • Backlighting
  • Standard needles 0.6, 1.0, 1.5 and 2.0mm, Custom needles 3.0 and 5.0mm

Video Demonstration

Click here for Video Demonstration.

Specifications

 TMA Tiss-OneTMA CK 2500TMA CK 3500 BasicTMA CK 3500 AdvancedTMA CK 4500TMA AutoTiss-10c
Specimen MovementSemi-AutomaticSemi-AutomaticAutomated Computer-AssistedAutomated Computer-AssistedAutomated Computer-AssistedFully Automatic
Automated Stage ModelISE EngineeredPrior Scientific ES111
Optiscan Upright Stage
Prior Scientific ES111
Optiscan Upright Stage
Prior Scientific H138 Stage
Stage Travel25.4 x 25.4mm123 x 77mm125 x 77mm125 x 77mm240 x 77mm
Stage SpeedXY 100mm/s1µm/s - 8mm/s1µm/s - 8mm/s1µm/s - 8mm/sUp to 60mm/sXY 300mm/s
Z 100mm/s
Repeatability+/-10µm/Axis5-7µm5-7µm5-7µm1-2µm+/-10µm/Axis
Resolution10µm/Axis1µm1µm1µm0.01µm10µm/Axis
User InterfaceTablet PC/Windows 8TouchscreenUser friendly dedicated software for TMA designing/constructing/reporting and picking & dispensing
1D and 2D Barcode Reader--OptionalOptionalStandardStandard
Donor/Recipient PositioningFixedFreeFreeFreeFreeFree
Modularity of the Specimen Holder---LowHigh-
Standard Histological Cassettes1+1Up to 6Up to 6Up to 6Up to 9Up to 10
Macro Blocks---1Up to 3-
Customise Paraffin Blocks----1 (up to 125 x 85mm)-
Microtiter Plates------
Microfuge Vials (1.5 - 2.0mL)---Up to 12Up to 14-
Glass Slides (Std & Macro)--OptionalOptionalStandard-
Cassette Backlighting-YesYesYesYesYes
Needle Size for Standard Blocks (on Request with Special needle Holder)3.0 & 5.0mm3.0 & 5.0mm3.0 & 5.0mm3.0 & 5.0mm
Needle Sizes for Macro Blocks---1.0, 1.5 & 2.0mm dia.1.0, 1.5 & 2.0mm dia.-
Core Punching
Needle PositioningManualAutomaticHigh resolution optics (Jenoptik Probes SpeedXT Core 3 CCD Camera) for easy identification of the punch areas on the donor blocks13megapixel High-resolution camera with Autofocus
regulation of Core Insertion DepthManualManualManualManualAutomatics
Punch Area SelectionVisual selection Glass Slide matchingDedicated software functions to selectively by (mouse click) on manual/digital on overlapping block & slide mages13MP
Core SelectionManualManualDedicates software functions to effectively {mouse click} on digital overlapping block or slide images.
Throughput (Cores/hr)1040606090150
Benchspace Required (cm)40 x 35 x 6032 x 50 x 6075 x 165 x 8075 x 165 x 8075 x 180 x 8075 x 180 x 80
Weight (kg)51235405555

Autotiss One – Semi-Automatic Tissue Arrayer

Galileo TMA CK4500 Tissue Microarrayer

Galileo TMA CK3500 Tissue Microarrayer

Galileo TMA CK2500 Tissue Microarray Systems

AutoTiss One – Semi-Automated Tissue Microarray Systems

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